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International Journal of Molecular Sciences

dc.contributor.authorSajewicz-Krukowska, Joanna
dc.contributor.authorMirosław, Paweł
dc.contributor.authorJastrzębski, Jan Paweł
dc.contributor.authorDomańska-Blicharz, Katarzyna
dc.contributor.authorTarasiuk, Karolina
dc.contributor.authorMarzec-Kotarska, Barbara
dc.date.accessioned2023-11-15T07:14:03Z
dc.date.available2023-11-15T07:14:03Z
dc.date.issued2023
dc.identifierhttps://dspace.piwet.pulawy.pl/xmlui/handle/123456789/568
dc.identifier.issn1422-0067
dc.identifier.urihttps://www.mdpi.com/1422-0067/24/20/15128
dc.description.abstractmiRNAs represent ubiquitous regulators of gene expression and play an important and pivotal regulatory role in viral disease pathogenesis and virus-host interactions. Although previous studies have provided basic data for understanding the role of miRNAs in the molecular mechanisms of viral infection in birds, the role of miRNAs in the regulation of host responses to chicken astrovirus (CAstV) infection in chickens is not yet understood. In our study, we applied next-generation sequencing to profile miRNA expression in CAstV-infected chickens and to decipher miRNA-targeted specific signaling pathways engaged in potentially vital virus-infection biological processes. Among the 1354 detected miRNAs, we identified 58 mature miRNAs that were significantly differentially expressed in infected birds. Target prediction resulted in 4741 target genes. GO and KEGG pathway enrichment analyses showed that the target genes were mainly involved in the regulation of cellular processes and immune responses.
dc.language.isoen
dc.publisherMDPI, Switzerland
dc.subjectRNA-seq
dc.subjectchicken astrovirus
dc.subjectmicroRNA
dc.subjectmolecular pathogenesis
dc.subjectspleen
dc.subjectwhite chicks syndrome
dc.titlemiRNA Expression Signatures Induced by Chicken Astrovirus Infection in Chickens
dcterms.bibliographicCitation2023 vol. 24 nr 20, 15128
dcterms.titleInternational Journal of Molecular Sciences
dc.identifier.doidoi: 10.3390/ijms242015128


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