Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy

    • Zaloguj
    Zobacz pozycję 
    •   Strona główna Repozytorium
    • PIWet - PIB
    • Publikacje
    • Zobacz pozycję
    •   Strona główna Repozytorium
    • PIWet - PIB
    • Publikacje
    • Zobacz pozycję
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Attempting to identify bacterial allies in immunotherapy of NSCLC patients

    Cancers

    Thumbnail
    Oglądaj/Open
    cancers-14-06250.pdf (4.111MB)
    Data
    2022
    Autor
    Grenda, Anna
    Iwan, Ewelina
    Krawczyk, Paweł
    Frąk, Małgorzata
    Chmielewska, Izabela
    Bomba, Arkadiusz
    Giza, Aleksandra
    Rolska-Kopińska, Anna
    Szczyrek, Michał
    Kieszko, Robert
    Kucharczyk, Tomasz
    Jarosz, Bożena
    Wasyl, Dariusz
    Milanowski, Janusz
    Metadane
    Pokaż pełny rekord
    Streszczenie
    Introduction: Factors other than PD-L1 (Programmed Death Ligand 1) are being sought as predictors for cancer immuno- or chemoimmunotherapy in ongoing studies and long-term ob- servations. Despite high PD-L1 expression on tumor cells, some patients do not benefit from im- munotherapy, while others, without the expression of this molecule, respond to immunotherapy. Attention has been paid to the composition of the gut microbiome as a potential predictive factor for immunotherapy effectiveness. Materials and Methods: Our study enrolled 47 Caucasian patients with stage IIIB or IV non-small cell lung cancer (NSCLC). They were eligible for treatment with first- or second-line immunotherapy or chemoimmunotherapy. We collected stool samples before the administration of immunotherapy. We performed next-generation sequencing (NGS) on DNA isolated from the stool sample and analyzed bacterial V3 and V4 of the 16S rRNA gene. Results: We found that bacteria from the families Barnesiellaceae, Ruminococcaceae, Tannerellaceae, and Clostridiaceae could modulate immunotherapy effectiveness. A high abundance of Bacteroidaaceae, Barnesiellaceae, and Tannerellaceae could extend progression-free survival (PFS). Moreover, the risk of death was significantly higher in patients with a high content of Ruminococcaceae family (HR = 6.3, 95% CI: 2.6 to 15.3, p < 0.0001) and in patients with a low abundance of Clostridia UCG-014 (HR = 3.8, 95% CI: 1.5 to 9.8, p = 0.005) regardless of the immunotherapy line. Conclusions: The Clostridia class in gut microbiota could affect the effectiveness of immunotherapy, as well as the length of survival of NSCLC patients who received this method of treatment.
    URI
    https://www.mdpi.com/2072-6694/14/24/6250
    Zbiory
    • Publikacje [640]

    DSpace software copyright © 2002-2016  DuraSpace
    Kontakt z nami | Wyślij uwagi
    Theme by 
    Atmire NV
     

     

    Przeglądaj

    Całe RepozytoriumZbiory i kolekcjeDaty wydaniaAutorzyTytułyTematyTa kolekcjaDaty wydaniaAutorzyTytułyTematy

    Moje konto

    Zaloguj

    Statystyki

    Przejrzyj statystyki użycia

    DSpace software copyright © 2002-2016  DuraSpace
    Kontakt z nami | Wyślij uwagi
    Theme by 
    Atmire NV