The effect of pegbovigrastim injection on phagocytic and oxidative burst activities of peripheral blood granulocytes and monocytes in calves challenged with Mycoplasma bovis
Pathogens
Oglądaj/ Open
Data
2022Autor
Dudek Katarzyna
Szacawa Ewelina
Wasiak Magdalena
Bednarek Dariusz
Reichert Michał
Metadane
Pokaż pełny rekordStreszczenie
Mycoplasma bovis (M. bovis) is an important pathogen affecting cattle, causing various
diseases including pneumonia which mainly occurring in calves. Control of M. bovis infections is
difficult due to the lack of commercial vaccines in most parts of the world and increasing trends of
antimicrobial resistance in field isolates of the pathogen; therefore, it seems reasonable to look for
new solutions for the prevention of the infection. Pegbovigrastim is a pegylated form of naturally
occurring circulating cytokine in cattle that affects bovine leukocytes and some cell functions. Most
studies on pegbovigrastim have focused on reducing the occurrence of mastitis and other diseases
occurring during the periparturient period in cows, while this study attempts to use pegbovigrastim
in the prevention of respiratory diseases in calves, which are largely caused by M. bovis. Based on
previous observations on the immunostimulatory properties of pegbovigrastim in cattle, for the
first time, the effect of its injection on the number and phagocytic and oxidative burst activities of
peripheral blood granulocytes and monocytes in calves experimentally infected with M. bovis was
investigated. Pegbovigrastim administration in the calves significantly stimulated an increase in
peripheral blood granulocyte and monocyte counts and phagocytic activity of the cells, especially
granulocytes, which was also generally expressed in the course of M. bovis infection. In response
to pegbovigrastim administration, a general increase in the oxygen burst activity of the cells was
observed. This effect was also shown despite ongoing infection with M. bovis which, taken together,
may indicate a beneficial effect of pegbovigrastim injection on the immunity of the affected animals.
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