Enterococci—Involvement in Pathogenesis and Therapeutic Potential in Cancer Treatment: A Mini-Review
Pathogens
Oglądaj/ Open
Data
2022Autor
Grenda, Anna
Grenda, Tomasz
Domaradzki, Piotr
Kwiatek, Krzysztof
Metadane
Pokaż pełny rekordStreszczenie
Enterococcus spp. are Gram-positive, heterogeneous lactic acid bacteria inhabiting various
environments. Several species of Enterococci are considered to be able to stimulate the immune
system and play an important role in intestinal homeostasis. Some Enterococci can be used as
probiotics. Some strains of E. faecium are components of pharmaceutical products used to treat
diarrhea, antibiotic-associated diarrhea, or irritable bowel syndrome (IBS). However, it has been
proved that they are responsible for food contamination, and are sometimes undesirable from the
point of view of food technology. Additionally, the virulence and multi-drug resistance of Enterococci
potentially pose a risk of an epidemic, especially in hospital environments. Moreover, there are
indications of their negative role in colon tumorigenesis; however, some nterococci are proved to
support immunotherapy in cancer treatment. In general, it can be concluded that this group of
microorganisms, despite its nature, has properties that can be used to support cancer treatment—both
aggressive chemotherapy and cutting-edge therapy targeting immune checkpoints (IC.
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